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| Registros recuperados: 21 | |
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| Demir,F.; Güzel,A.; Katı,C.; Karadeniz,C.; Akdemir,U.; Okuyucu,A.; Gacar,A.; Özdemir,S.; Güvenç,T.. |
| Cardiac contusion is a potentially fatal complication of blunt chest trauma. The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. Thirty-five female Sprague-Dawley rats were divided into five groups (n=7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg·kg−1·day−1), and treated with a combination of methylprednisolone and quercetin. Serum troponin I (Tn-I) and tumor necrosis factor-alpha (TNF-α) levels and cardiac histopathological findings were evaluated. Tn-I and TNF-α levels were elevated after contusion (P=0.001 and P=0.001). Seven days later, Tn-I and TNF-α... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Blunt chest trauma; Cardiac contusion; Quercetin; Methylprednisolone; INOS. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000900766 |
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| Mallhi,Tauqeer Hussain; Qadir,Muhammad Imran; Khan,Yusra Habib. |
| In-vitro investigation of Morus nigra L. (Moraceae) has demonstrated the evidence of several antioxidant compounds. Current study was aimed to determine the phytoconstituents and hepatoprotective potential of n-hexane extract of Morus nigra. Swiss albino mice were divided into five groups: normal control, paracetamol control, silymarin control, 250 mg/kg p.o. extract for 7 days plus paracetamol 3 h later, 500 mg/kg p.o. extract for 7 days plus paracetamol 3 h later. Serum levels of liver enzymes and total bilirubin were assessed and compared between the groups by using one-way ANOVA to confirm hepatoprotective activity. HPLC analysis revealed the presence quercetin, oleanolic acid, luteolin, apigenin, vitamin C and kuwanon C. n-hexane extract of Morus... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Moraceae; HPLC; Quercetin; Morus nigra/antioxidant; Morus nigra/extract/hepatoprotective. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300631 |
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| Pereira Alves,Angela Maria; de Paula,Anderson Luiz; Moreira,Cassio Rafael; Ferrari,Fernanda; Coelho Leal,Jean Paulo; Hatoum,Ualid Saleh; Vieira Silva,Helaine Maruska; Belato Alves,Eder Paulo; de Miranda Neto,Marcilio Hubner; Galvanini,Paulo Alexandre. |
| The effects of quercetin supplementation in NADH-diaphorase positive (NADH-d) neurons of streptozotocin-induced diabetic rats was carried in this study. Fifteen male rats were divided into three groups: normoglycemic (N), diabetic (D) and diabetic supplemented with quercetin (DQ). Whole mount preparations of the muscular layer of the ileum underwent NADH-d histochemistry for evidencing the NADH-d neuronal subpopulation. Quantitative analyzes were performed on 30 random fields, and morphometric analyzes in 100 neuronal bodies and nuclei per animal. The supplementation promoted a 44 % reduction in the neuronal density in D group when compared to N group (p <0.001); a 24.5 % reduction was observed in the DQ group when compared to N (p <0.01). Animals in... |
| Tipo: Journal article |
Palavras-chave: Diabetes mellitus; Enteric neurons; Quercetin; NADH diaphorase. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100039 |
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| Shourie,Abhilasha; Tomar,Pushpa; Srivastava,Deepika; Chauhan,Rahul. |
| Lycopersicon esculentum respond to UV-B by enhanced synthesis of flavonoid quercetin, a strong antioxidant that helps the plants to well acclimatize to UV-B stress. Three weeks old plants of L. esculentum were subjected to acute UV-B irradiation for 20, 40 and 60 minutes daily until 28 days and analyzed for the morphological and biochemical changes. UV-B exposure for 40 and 60 minutes considerably affected the growth and biomass of L. esculentum. The leaves were deformed, developed chlorosis and abscised early as compared to the unexposed plants. Biomass declined by 35% and total chlorophyll decreased by 24.7% due to disintegration of chloroplasts. Enhancement was seen in the content of carotenoids, anthocyanins and total flavonoids by 15, 33.3 and 22.8%,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: UV-B; Lycopersicon esculentum; Quercetin; Biomass; Pigments; Anthocyanins. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000300002 |
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| Barros,Pedro Paulo; Silva,Gustavo Henrique da; Gonçalves,Gisele Mara Silva; Oliveira,Jessica Cristiane; Pagnan,Livia Gonçalves; Arco-e-Flexa,Luiza. |
| ABSTRACT Quercetin has potent antioxidant action and a hepatoprotective role. The aim of this study was to evaluate the hepatoprotective action of quercetin pretreatment in paracetamol-induced liver damage (PILD) and structural injury resulting from partial hepatectomy (PH). In the first model, Wistar rats received oral quercetin (50mg/kg/day) during 8 days. On the 8th day, 3g/kg paracetamol were added. In the second model, the same quercetin dose was given during 7 days and rats were submitted to PH on the 8th day. Blood samples were obtained for determination of enzyme levels. Liver, heart, kidney and lung tissue were also collected for assessment of quercetin biodistribution and/or histological analyses. The results obtained after PILD were more... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quercetin; Paracetamol; Partial hepatectomy; ALT; AST. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100302 |
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| Jesus,Roberta S.; Piana,Mariana; Freitas,Robson B.; Brum,Thiele F.; Alves,Camilla F.S.; Belke,Bianca V.; Mossmann,Natália Jank; Cruz,Ritiel C.; Santos,Roberto C.V.; Dalmolin,Tanise V.; Bianchini,Bianca V.; Campos,Marli M.A.; Bauermann,Liliane de Freitas. |
| Abstract The main objective of this study was to demonstrate the antimicrobial potential of the crude extract and fractions of Chenopodium ambrosioides L., popularly known as Santa-Maria herb, against microorganisms of clinical interest by the microdilution technique, and also to show the chromatographic profile of the phenolic compounds in the species. The Phytochemical screening revealed the presence of cardiotonic, anthraquinone, alkaloids, tannins and flavonoids. The analysis by HPLC-DAD revealed the presence of rutin in the crude extract (12.5 ± 0.20 mg/g), ethyl acetate (16.5 ± 0.37 mg/g) and n-butanol (8.85 ± 0.11 mg/g), whereas quercetin and chrysin were quantified in chloroform fraction (1.95 ± 0.04 and 1.04 ± 0.01 mg/g), respectively. The most... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amaranthaceae; Antimicrobial potential; Rutin; Quercetin; Chrysin. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200296 |
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| Ahmad,S; Khalique,A; Pasha,TN; Mehmood,S; Ahmad,S Sohail; Khan,AM; Hussain,K. |
| ABSTRACT Phytogenic feed additives have been increasingly used in the last decade, and several plants and their metabolites have been investigated for the said purpose. In this context, present study aimed at evaluating the effects of Moringa oleifera as feed additive on layer performance, and egg bioactive compound levels and nutrient profile. HyLine W36 layers (n=200), 50 weeks of age, were randomly distributed in four treatments with five replicates of ten birds each. Four isocaloric (2725 kcal/kg) and isonitrogenous (CP 16%) diets were formulated and supplemented with 0, 0.5, 1.0, or 1.5% (w/w) of dried Moringa oleifera leaf powder (MLM). The results showed positive effects of MLM on egg production, egg mass, and feed conversion ratio, but negative... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Β-carotene; Moringa leaf; Quercetin; Production performance; Serum biochemistry. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2018000200325 |
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| Wan,Y.; Tang,M.H.; Chen,X.C.; Chen,L.J.; Wei,Y.Q.; Wang,Y.S.. |
| Immune response plays an important role in the development of hepatic fibrosis. In the present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis induced by immunological mechanism. In the acute hepatitis model, quercetin (2.5 mg/kg) was injected iv into mice 30 min after concanavalin A (Con A) challenge. Mice were sacrificed 4 or 24 h after Con A injection, and aminotransferase tests and histopathological sections were performed. Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Consistent with this observation, treatment with quercetin markedly attenuated the pathologic changes in the liver. A hepatic fibrosis model was also generated in mice... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quercetin; Concanavalin A; Acute hepatitis; Hepatic fibrosis; Liposome. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000800655 |
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| Dajas,F.; Rivera-Megret,F.; Blasina,F.; Arredondo,F.; Abin-Carriquiry,J.A.; Costa,G.; Echeverry,C.; Lafon,L.; Heizen,H.; Ferreira,M.; Morquio,A.. |
| The high morbidity, high socioeconomic costs and lack of specific treatments are key factors that define the relevance of brain pathology for human health and the importance of research on neuronal protective agents. Epidemiological studies have shown beneficial effects of flavonoids on arteriosclerosis-related pathology in general and neurodegeneration in particular. Flavonoids can protect the brain by their ability to modulate intracellular signals promoting cellular survival. Quercetin and structurally related flavonoids (myricetin, fisetin, luteolin) showed a marked cytoprotective capacity in in vitro experimental conditions in models of predominantly apoptotic death such as that induced by medium concentrations (200 µM) of H2O2 added to PC12 cells in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Flavonoids; Quercetin; Focal ischemia; Neuroprotection. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200002 |
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| SOUZA,M.; COMIN,J.J.; KURTZ,C.; LOVATO,P.E.; LIMA,A.P.; KUHNEN,S.. |
| ABSTRACT: The identification of compounds with allelopathic potential produced by cover crops can assist in selecting species for weed management purposes in no-tillage systems. This study aimed to identify the main phenolic compounds with allelopathic potential in the shoot of rye (Secale cereale L.) and oilseed radish (Raphanus sativus L.) cover crops, as well as evaluate whether the cultivation system and phenological stage may influence secondary metabolite production and weed emergence. Samples of the shoot of these cover crops were collected at 60, 80, and 100 days after sowing (DAS) and 15 and 30 days after lodging (DAL) under field conditions. Weed emergence was evaluated at 45, 75, and 100 DAL of cover crops. The main compounds in rye were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cover crops; Allelopathy; Quercetin; BOA; MBOA. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582019000100287 |
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| Li,X.; Chen,Y.; Wang,L.; Shang,G.; Zhang,C.; Zhao,Z.; Zhang,H.; Liu,A.. |
| Quercetin shows protective effects against hepatopulmonary syndrome (HPS), as demonstrated in a rat model. However, whether these effects involve pulmonary vascular angiogenesis in HPS remains unclear. Therefore, this study aimed to assess the effect of quercetin on pulmonary vascular angiogenesis and explore the underlying mechanisms. Male Sprague-Dawley rats weighing 200-250 g underwent sham operation or common bile duct ligation (CBDL). Two weeks after surgery, HIF-1α and NFκB levels were assessed in rat lung tissue by immunohistochemistry and western blot. Then, CBDL and sham-operated rats were further divided into 2 subgroups each to receive intraperitoneal administration of quercetin (50 mg/kg daily) or 0.2% Tween for two weeks: Sham (Sham+Tween;... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Angiogenesis; Hepatopulmonary syndrome; HIF-1α; Quercetin. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000700606 |
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| Bin-Jaliah,Ismaeel. |
| Complications of chronic stress including cardiovascular disease are among the common public health problems that affect the lives of millions of people around the globe. We sought to determine whether the anti-oxidant and anti-apoptotic agent, quercetin can inhibit chronic stress-induced left ventricular dysfunction (LVD). Chronic unpredictable stress (CUS) was induced in rats using a variety of stressors in the presence and absence of quercetin (50 mg/kg body weight/day). Harvested tissues from the left ventricles (LV) of these animals were examined using basic histological staining. In addition, LV tissue homogenates were assayed for markers of oxidative and anti-oxidative stress that are known to be modulated in cardiac dysfunction. Furthermore, LV... |
| Tipo: Journal article |
Palavras-chave: Quercetin; Chronic stress; Heart failure; Left ventricular dysfunction; Antioxidant; Apoptosis. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200044 |
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| Wang,Y.; Zhang,Z.Z.; Wu,Y.; Ke,J.J.; He,X.H.; Wang,Y.L.. |
| Quercetin (Que), a plant-derived flavonoid, has multiple benefical actions on the cardiovascular system. The current study investigated whether Que postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. Male Sprague-Dawley rats were randomly allocated to 5 groups (20 animals/group): sham, I/R, Que postconditioning, Que+LY294002 [a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway inhibitor], and LY294002+I/R. I/R was produced by 30-min coronary occlusion followed by 2-h reperfusion. At the end of reperfusion, myocardial infarct size and biochemical changes were compared. Apoptosis was evaluated by both TUNEL staining and measurement of activated caspase-3... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ischemia and reperfusion; Quercetin; Postconditioning; PI3K/Akt. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000861 |
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| Registros recuperados: 21 | |
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